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Using a Hierarchical Research Approach in Musculoskeletal Disease and Injury Research

Release time:January 16, 2019

Topic: Using a Hierarchical Research Approach in Musculoskeletal Disease and Injury Research

Speaker: Prof.Lee, The University of Melbourne

Time:January 18, at 14:00

Venue: Room 317, Yifu Science Center, Beihang University

Abstract:

The overarching aim of our laboratory is to understand how forces are applied to the human, transferred to the tissue and transduced into biological responses. This presentation will highlight examples on how we apply a hierarchical research approach for biomedical applications. In the area of musculoskeletal injury prevention, we have conducted investigations using human volunteers, cadavers as experimental surrogates and computational models, to help advanced our understanding of clinical symptoms, pathological evidence and injury mechanism. Another focus area is Osteoarthritis (OA), a condition affecting the joints, and is a leading cause of chronic pain and disability worldwide. Any attempt to halt the progression of OA through physical rehabilitation or drug therapies, or reparative surgery using new implant materials, will require quantitative knowledge of bone and cartilage structure. We have developed multi-scale techniques to apply physiological loads on cartilage and bone via human motion experiments and mechanical testing systems. Computation models were used to probe the load bearing abilities of cartilage/bone affected by OA, to help advance our understanding of the disease process. In another example, we have used similar hierarchical approaches to design temporomandibular joint implant using musculoskeletal modelling techniques, before being 3D printed in titanium and implanted into the patient.

Biography of the Speaker:

Peter Lee obtained his BEng in Mechanical Engineering (1st Class Hons. 1991) and PhD (1996) in Bioengineering from the University of Strathclyde, UK, and continued his post-doc in the same university from 1996–1998. He was a Research Fellow with the Biomaterials Group at the Institute of Materials Research and Engineering, Singapore from 1998–2001. In 2001, he joined the Defence Medical and Environmental Research Institute, DSO National Laboratories, Singapore, as the Head of the Bioengineering Laboratory. DSO is the largest research institute in Singapore with 1500 researchers. Lee accumulated significant experience in managing multi-million dollar defence research projects and infrastructure. He pioneered the Bioengineering Laboratory and the Biotechnology Programme in DSO and achieved noteworthy recognitions and awards for his research and management skills. In his career, he had undergone formal management training by the Ministry of Defence Singapore and the IMD Business School Switzerland. He joined the University of Melbourne, Australia, as a Senior Lecturer in 2008, and was promoted to an Associate Professor in 2011 and a Professor in 2015. Since then he has held several leadership positions including Deputy Head and Acting Head of Department of Mechanical Engineering, and currently as the Deputy Head (Research and Engagement) of Department of Biomedical Engineering, and the Melbourne School of Engineering Research Program Leader for Medical and Pharmaceutical Technologies. He also leads the Cell and Tissue Biomechanics Laboratory in Engineering, where his research aims to better understand the behaviour of biological cells and tissues under mechanical forces. He has authored more than 140 publications in journals, conference proceedings and books. He is a and currently the Deputy Editor for Journal of Orthopaedic Surgery and Research, and Associate Editor for Frontiers in Pharmacology (Translational Pharmacology).

 

 

School of Biological Science and Medical Engineering